Isoflex™ Active Overview
Isoflex™ active is the trade name of Bixlozone, a new herbicide ingredient from the isoxazolidine family discovered and developed by the FMC research and development organization. It offers growers operational flexibility and lasting control of key grass weeds, including those with developed resistance to other mode of action herbicides, as well as a range of broadleaf weeds. Early season application timing enables growers to maximize productivity across multiple crop segments.

Isoflex™active, a new isoxazolidinone herbicide, inhibits the carotenoid biosynthesis in susceptible plants – carotenoids are pigments that are critical to protecting photosynthetic processes and ensure normal plant growth and development. Due to a lack of chlorophyll production, susceptible plants may show chlorosis and/or bleaching symptoms and ultimately die off. Studies of tolerant crops show that these symptoms are transient with no effect on the vigor and yield.
Isoflex™ active represents a new and unique selective residual weed control solution in a wide range of crops including, cereals,
Weed resistance is a global concern, but the specific challenges vary at the local level, and so should the weed management tactics. Reference the HRAC, AUS, and WSSA classifications of herbicides to plan the appropriate herbicide mixtures or rotations within an integrated weed management system, including crop rotation. Isoflex™ active is a new active ingredient that is classified as an HRAC Group 13. As only the second active substance belonging to the isoxazolidinone family, Isoflex™ active will offer a new rotational product and a valuable tool for resistance management, especially in cereals. Isoflex™ active will also be a complementary mixing partner for broadleaf herbicides as it can extend the utility of existing products by expanding the spectrum of weeds controlled. While herbicides are one tool for weed control, FMC also supports integrated weed management programs that utilize a wide variety of weed control practices to ensure that herbicides remain as sustainable tools.
Weeds reduce yields by competing for space, light, water, and nutrients, weakening crop stand, and by reducing harvest efficiency. Effective weed management involves developing a sound herbicide strategy to control weeds at crucial points throughout the season. Pre-emergence herbicides are important for controlling weeds after the seeds germinate, until 2-3 leaves. Pre-emergent herbicides are key to reducing weed pressure and removing competition early in the growing season. Isoflex™ active provides both systemic and contact activity, with residual control. The herbicide can be applied pre-emergence or early post-emergence, across a wide range of agronomic environments.